Histone H3 (tri methyl K4) Recombinant Rabbit mAb (S-4099)
SKU: 95986887472

Histone H3 (tri methyl K4) Recombinant Rabbit mAb (S-4099)

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Description

Histone H3 (tri methyl K4) Recombinant Rabbit mAb (S-4099)Product Specification Host Rabbit Antigen Histone H3 (tri methyl K4) Synonyms H3K4me3 Location Nucleus Accession P68431 Clone Number S 4099 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC, ChIP Reactivity Hu, Ms, Rt Positive Sample HeLa, NIH 3T3, C6 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12

Product Specification


Host Rabbit
Antigen Histone H3 (tri methyl K4)
Synonyms H3K4me3
Location Nucleus
Accession P68431
Clone Number S-4099
Antibody Type Recombinant mAb
Isotype IgG
Application WB, ICC, ChIP
Reactivity Hu, Ms, Rt
Positive Sample HeLa, NIH/3T3, C6
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20°C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt
ICC 1:500 Hu, Ms
ChIP 1:20-1:50 Hu

Background

Histone H3 lysine 4 trimethylation (commonly denoted as H3K4me3) is a crucial epigenetic modification on the tail of core histone H3 that plays a central role in regulating gene transcription. It is primarily catalyzed by histone methyltransferases from the COMPASS/COMPASS-like family (such as MLL1-4 and SET1A/B) and is specifically recognized by "reader" proteins containing PHD domains (e.g., Taf3 and ING family proteins). The genomic distribution of H3K4me3 is highly characteristic: it is strongly enriched at the promoter regions of actively transcribed genes, particularly near transcription start sites, marking a "primed for activation" state. This modification facilitates the formation of open chromatin structures and the assembly of the transcription initiation complex by recruiting chromatin remodelers, general transcription factors, and histone acetyltransferases, thereby positively regulating gene expression. H3K4me3 is essential for maintaining pluripotency in embryonic stem cells, cell fate determination, and processes such as learning and memory. Notably, its dysregulation—whether excessive or deficient—is closely associated with various developmental disorders and cancers (such as leukemia and breast cancer). Consequently, H3K4me3 is not only a vital biomarker in fundamental research but also a potential target for disease diagnosis and therapy.

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SKU: 95986887472

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4.3 ★★★★★
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A
Verified Purchase
Amazon Customer shannon
Alexandria, US
★★★★★ 5
Great quality & interest
Keeps my Shepard/Husky occupied for 30+ minutes. She hasn't even destroyed it.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 10, 2025
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Verified Purchase
Beth4011
Charlottesville, US
★★★★★ 4
Good for medium and large dogs not good for small dogs
Too big for dogs under 15 pounds. Treats are hard to get out of the four corners. My dog can barely pick this up. She weighs 12 pounds. She still found it interesting though trying to dig the treats out that she was unsuccessful. Even after I cut all the little triangle prongs off the four corners the treats are still stuck in there. There is a slot on the side that I can put half of a dental refill in the side and she can eventually get it out so there’s still somewhat of play and challenge received, but not that satisfied to me.
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Reviewed in the United States on October 3, 2025
A
Verified Purchase
Amazon Customer
Phoenix, US
★★★★★ 5
Great for aggressive chewers!
Size: Jumbo, Style: Peanut Butter
I have a very very aggressive chewer. She is a Rottweiler/Pitbull mix. Most toys she completely destroys within 2 days, sometimes 2 hours. I must praise this toy as she has had it for over 5 months and has not destroyed it! She loves chewing the ends and carries in her mouth squeaking it as she goes. I have 4 pups and they all take turns chewing when they can. I will be buying more Playology dog toys in the future. Thank you for making such a great toy!!
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Reviewed in the United States on April 26, 2026
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Verified Purchase
Steven Turner
Belleville, US
★★★★★ 5
They are her favorites
Size: Medium (VALUE 2-Pack), Style: Beef, Size: Medium (VALUE 2-Pack), Style: Beef
We’ve had many dogs, many very destructive ones and wish I had these years ago. The hard toys get sharp edges, this toy is the best and yes is far better than the other red ones. My bulldog wants tug of war for 30 min to an hour every night. We’ve gotten tennis elbow, tendinitis, and pulled muscles holding onto this thing. She has tons of toys but 9pm and this is only option for her. We don’t get a choice. Easy to hold, well for a few min until your hand gets tired. First you one was about 3 years ago and she’s only on her third one. They last forever, easy to clean, and aren’t sharp edges. Seriously, better than any toy sold anywhere. My phone has hundred of pictures of Pickle holding this. She’s doing it right now. If you have a strong destructive dog that takes pride in destroying toys, ruin their confidence and get them this one.
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Reviewed in the United States on April 5, 2026
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Lake Worth, US
★★★★★ 5
Perfect Toy for Large Dogs
Size: Medium, Style: Cheddar Cheese
I don’t normally leave reviews, but this toy is stellar and is a new favorite for my dog! She is a large dog (70lbs cattle dog lab mix) and I accidentally bought a medium, but it actually is a great size for her! So far this stands up to her chewing, but I may need to update in a few weeks to speak for durability but it really does feel solid. Most toys don’t last an afternoon once she starts chewing, so this has already won in that regard. The shape is perfect as well. She can gnaw at it, squeak, play fetch, play tug. It bounces when she throws it around herself. The fact it smells like stinky cheese is just an added bonus for her. All around, a very well designed dog toy!
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Reviewed in the United States on December 27, 2023

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