Histone H3 (tri methyl K4) Recombinant Rabbit mAb (S-4099)
SKU: 79594471885

Histone H3 (tri methyl K4) Recombinant Rabbit mAb (S-4099)

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Description

Histone H3 (tri methyl K4) Recombinant Rabbit mAb (S-4099)Product Specification Host Rabbit Antigen Histone H3 (tri methyl K4) Synonyms H3K4me3 Location Nucleus Accession P68431 Clone Number S 4099 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC, ChIP Reactivity Hu, Ms, Rt Positive Sample HeLa, NIH 3T3, C6 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12

Product Specification


Host Rabbit
Antigen Histone H3 (tri methyl K4)
Synonyms H3K4me3
Location Nucleus
Accession P68431
Clone Number S-4099
Antibody Type Recombinant mAb
Isotype IgG
Application WB, ICC, ChIP
Reactivity Hu, Ms, Rt
Positive Sample HeLa, NIH/3T3, C6
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20°C as supplied

Dilution


application dilution species
WB 1:1000 Hu, Ms, Rt
ICC 1:500 Hu, Ms
ChIP 1:20-1:50 Hu

Background

Histone H3 lysine 4 trimethylation (commonly denoted as H3K4me3) is a crucial epigenetic modification on the tail of core histone H3 that plays a central role in regulating gene transcription. It is primarily catalyzed by histone methyltransferases from the COMPASS/COMPASS-like family (such as MLL1-4 and SET1A/B) and is specifically recognized by "reader" proteins containing PHD domains (e.g., Taf3 and ING family proteins). The genomic distribution of H3K4me3 is highly characteristic: it is strongly enriched at the promoter regions of actively transcribed genes, particularly near transcription start sites, marking a "primed for activation" state. This modification facilitates the formation of open chromatin structures and the assembly of the transcription initiation complex by recruiting chromatin remodelers, general transcription factors, and histone acetyltransferases, thereby positively regulating gene expression. H3K4me3 is essential for maintaining pluripotency in embryonic stem cells, cell fate determination, and processes such as learning and memory. Notably, its dysregulation—whether excessive or deficient—is closely associated with various developmental disorders and cancers (such as leukemia and breast cancer). Consequently, H3K4me3 is not only a vital biomarker in fundamental research but also a potential target for disease diagnosis and therapy.

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SKU: 79594471885

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4.7 ★★★★★
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Product Reviews
M
Michelle DeRosa
West Palm Beach, US
★★★★★ 4
Solar light quit, soon after I got it, battery maybe, but I love the angel and its design.
Color: White, Color: White
Love the detail of the angel, the facials features the details in the wings love the rose vine! Great garden decor the solar lights only worked the first day i even checked the battery position and the on off switch, I am assuming the battery died, but I can get another solar light i still love the design.
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Reviewed in the United States on March 13, 2026
S
SB
Lowell, US
★★★★★ 5
Good Quality
Color: White
This is absolutely beautiful. The lighting is ambient and not bright, with a warm glow (not as bright as the photos), and the charge lasts about 3 hours, give or take. The plaster mold is done very well so that it looks high end. It is also high-quality because I dropped it and it didn't break. For this reason, the price is right. This would be a great gift, but also a wonderful ornament for the yard or even as a welcome at the front door.
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Reviewed in the United States on March 31, 2026
L
logan zaske
Massapequa, US
★★★★★ 3
Looks nice, and works well but the light doesn't fit well.
Color: White
I have mixed feelings about this little angel light. I got it for my mom, and she really loves it, and it looks great on the edge of the garden by the walkway up to the house. It doesn't provide a lot of light, but what it does offer is just enough at night to help people navigate until they're close enough for our motion activated porch light to turn on. The light however just doesn't come installed in the figure and doesn't fit very well into the hole it's supposed to sit in. I used some thick double sided tape as a gasket to hold it in place and solved the problem, but it's worth noting anyway. As for overall quality, it's ok, but not great. The figure is made of resin (plastic), and is fairly thin and not very strong. It's also very light and can be knocked or blown over by wind very easily. The casting on the angel itself is ok, but the socket the light sets into was misshapen and I also had to clean it up to even get the light to fit into it. (There was some flashing at the bottom of the hole that prevented it from sitting all the way down) Battery life seems to be pretty good, and lasts through the night as long as it gets enough sun during the day, but on cloudy days it tends to only last a few hours at most. And the light sensor does work well, it comes on right at dusk. As for value I'm not sure I'd say it's a great deal for the current price, but if you can find it on sale might be worth getting. Of course on anything decorative value is subjective and depends largely on how much you like the look of it. As always if I encounter any other issues or think of anything else to add I'll update this review!
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Reviewed in the United States on March 4, 2026
A
Amanda Scarberry
New York, US
★★★★★ 5
solar figurine
Color: White
I recently added these angel figurines to my garden, and they are absolutely lovely. The solar-powered feature lights them up at night, creating a soft, peaceful glow that highlights my patio and lawn beautifully. The statues are well-crafted and durable, holding up nicely in sun and rain, and the white finish looks elegant against my greenery. They also make a thoughtful gift for moms or garden lovers. Overall, these are charming, functional, and decorative outdoor angel statues that add a serene touch to any garden or balcony.
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Reviewed in the United States on March 31, 2026
E
Erica
Lake Worth, US
★★★★★ 5
Beautifully made sturdy angel statue!
Color: White
This outdoor angel statue is so well done! The craftmanship on it is amazing! Easy to hook in light. I do note that the light is a little wobbly in the holder section, but it looks fantastic! Lights up nicely! The wings and the detail on the angel really are well done. This statue is beautiful! It is pretty sturdy too. Looks well inside, but definitely will be a nice touch to my garden! Seems to be weather resistant as well!
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Reviewed in the United States on March 4, 2026

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