Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Jul 9 - Jul 14
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
FOXA1 Recombinant Rabbit mAb, PBS Only (SDT-2779-17)Product Specification Host Rabbit Antigen FOXA1 Synonyms Hepatocyte nuclear factor 3 alpha; HNF 3 alpha; HNF 3A; Forkhead box protein A1; Transcription factor 3A (TCF 3A); HNF3A; TCF3A Immunogen Recombinant Protein Location Nucleus Accession P55317 Clone Number SDT 2779 17 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, IF Reactivity Hu, Ms, Rt Positive Sample HepG2, PC 3, LNCaP, MCF7 Purification Protein A Concentration 1mg ml
Product Specification
| Host | Rabbit |
| Antigen | FOXA1 |
| Synonyms | Hepatocyte nuclear factor 3-alpha; HNF-3-alpha; HNF-3A; Forkhead box protein A1; Transcription factor 3A (TCF-3A); HNF3A; TCF3A |
| Immunogen | Recombinant Protein |
| Location | Nucleus |
| Accession | P55317 |
| Clone Number | SDT-2779-17 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, IF |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HepG2, PC-3, LNCaP, MCF7 |
| Purification | Protein A |
| Concentration | 1mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:200 | Hu |
| ICC | 1:500 | Hu |
| IF | 1:100 | Hu |
Background
FOXA1, a 46-kDa, 472-aa winged-helix/forkhead DNA-binding pioneer transcription factor, opens compacted chromatin by partial nucleosome unfolding, thereby enabling recruitment of steroid-hormone receptors and lineage-specific transcriptional programs that govern development, differentiation, and adult homeostasis of liver, pancreas, lung, prostate, and breast; in cancer it acts as a context-dependent tumor suppressor or oncogene—most notably driving estrogen-receptor-α (ERα) binding and luminal breast/prostate identity—through genomic rearrangements, hotspot mutations (e.g., R219S/W), or altered protein–protein interactions that reprogram enhancer landscapes, control epithelial–mesenchymal plasticity, and modulate therapeutic response to endocrine agents, making FOXA1 a critical determinant of lineage fidelity, drug sensitivity, and patient prognosis.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy