PFKL+PFKM Recombinant Rabbit mAb (S-1302-31)
SKU: 92778990577

PFKL+PFKM Recombinant Rabbit mAb (S-1302-31)

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Description

PFKL+PFKM Recombinant Rabbit mAb (S-1302-31)Product Specification Host Rabbit Antigen PFKL+PFKM Synonyms ATP dependent 6 phosphofructokinase, liver type; ATP PFK; PFK L; 6 phosphofructokinase type B; Phosphofructo 1 kinase isozyme B (PFK B); Phosphohexokinase; ATP dependent 6 phosphofructokinase, muscle type; PFK M; 6 phosphofructokinase type A; Phosphofructo 1 kinase isozyme A (PFK A); Phosphohexokinase; PFKX Immunogen Synthetic Peptide Location Cytoplasm Accession P17858 P08237 Clone Number S

Product Specification


Host Rabbit
Antigen PFKL+PFKM
Synonyms ATP-dependent 6-phosphofructokinase, liver type; ATP-PFK; PFK-L; 6-phosphofructokinase type B; Phosphofructo-1-kinase isozyme B (PFK-B); Phosphohexokinase; ATP-dependent 6-phosphofructokinase, muscle type; PFK-M; 6-phosphofructokinase type A; Phosphofructo-1-kinase isozyme A (PFK-A); Phosphohexokinase; PFKX
Immunogen Synthetic Peptide
Location Cytoplasm
Accession P17858、 P08237
Clone Number S-1302-31
Antibody Type Recombinant mAb
Isotype IgG
Application WB, IHC-P, ICC
Reactivity Hu, Ms, Rt
Positive Sample HeLa, A431, SK-BR-3, HCT 116, RAW264.7, NIH/3T3, C6, PC-12
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000-1:2000 Hu, Ms, Rt
IHC-P 1:2000 Hu, Ms, Rt
ICC 1:500 Hu

Background

PFKL and PFKM are tissue-specific isoforms of phosphofructokinase-1 (PFK-1) that catalyze the committed step of glycolysis by phosphorylating fructose-6-phosphate to fructose-1,6-bisphosphate; PFKL (≈83 kDa) forms homotetrameric L4 complexes most abundant in liver, whereas PFKM (≈85 kDa) forms homotetrameric M4 complexes predominant in muscle, yet both can co-assemble into heterotetramers (e.g., M3L, M2L2, ML3) in cells such as erythrocytes, enabling finely tuned allosteric regulation by metabolites (activated by ADP, AMP, fructose-2,6-bisphosphate; inhibited by ATP, citrate) and post-translational modifications (phosphorylation, GlcNAcylation, S-nitrosylation, ubiquitination) that integrate nutritional and energy stress signals to control glucose flux, NADPH balance, and downstream biosynthetic pathways critical for systemic glucose homeostasis, redox buffering, and cancer metabolic reprogramming.

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SKU: 92778990577

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4.8 ★★★★★
Based on 138 reviews
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Product Reviews
L
Verified Purchase
LJM
Port Orchard, US
★★★★★ 5
such a good read
Format: Kindle
Madison, Lucas, Grey and Rian were made for each other!!! First time reading from this author and I’m not disappointed!!! Absolutely love the Love in this book and couldn’t ask for a better OV!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 25, 2023
B
Verified Purchase
Beccaroo
Belleville, US
★★★★★ 4
Fluffy and Nice Omegaverse
Format: Kindle
… this would have made 5 stars but for 2 reasons. A.) there were quite a few typos; misspelled words, missing quotations, “the his” mistakes, and various signs that maybe a proofread would do good. B.) the writing was quite textbook. Late blooming omega is struggling with her new self, finds a absurdly wealthy pack of alphas, every thing is almost insta-love but she resists, then decides to love herself and let everyone be happy. Rian was my favourite (obviously the author’s favourite too because he got the most page time) but I wish we could see more of his CEO side? He went to work maybe ONCE the entire time. Gray was supposed to be the “growly one” but he turned out to be puppy dog. Lucas was a genius brainiac doctor - but also super alpha with an aggressive hindbrain with a breeding k*nk?? And then there was no actual “breeding”?? Spice 3/5 - normally omegaverse books are super high on messy smut but this was tamer. Romance 3/5 - insta-love that was then resisted because of personal hangup’s Plot 2/5 - weird paced head hopping, showing the same scene from different POV’s that made me feel like it was 2 steps backward, 1 step forward. Humour 4/5 - there were a dozen lines that genuinely made me chuckle out loud Would have been five stars but the lack of proofreading and the predictable plot made me unable to get up to ADORED IT level - four stars is still and official ENJOYED IT, y’all. This isn’t a bad rating. The “Club Heat” has intriguing possibilities so I’m going to give the second one a shot.
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Reviewed in the United States on March 31, 2023
R
Verified Purchase
Ruth Ann Burt
Omaha, US
★★★★★ 5
Great book
Format: Kindle
I absolutely feel in love with all 4 characters!!! The bedroom scenes were 🌋🌡🔥🔥🔥. I couldn't put this book down!!! I'm hooked for the whole series Book 2 here I come!!!!! Its a fun easy book and story to read!!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 4, 2024
D
Verified Purchase
Danyelle
Massapequa, US
★★★★★ 4
Fun with a late blooming omega
Format: Kindle
I like this book. The story is fun, cute, and sexy. There's just a little drama, some excellent, steamy scenes, and a fairly good relationship building storyline. I especially like how all the main characters are a bit older than the usual 20 somethings I tend to see in this kind of book. Having said that, I wish there were more descriptions of the places, as well as the food in the fancy restaurant. I enjoyed the cocktails at the club, so I missed that kind of detail when Gray took Madison on a dinner date. I also wish there had been more interaction between Lucas and Madison, and Lucas and Rian. It felt a bit lopsided, with a focus on Rian, Madison, and Gray. I wish it had been proofread - there are a lot of typos, but nothing too distracting.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 12, 2022
J
Verified Purchase
Jennifer G
Fort Morgan, US
★★★★★ 3
Madison Deserved Better
Format: Kindle
Madison was a beta...except she wasn't any longer. She was a late presenting Omega. And she was struggling. She was tall and thin, not tiny and curvy. She was opinionated. She was everything an Omega was not. After suffering through her first heat, her friends took her to Ardor, a club where Omegas came to safely find Alphas. She's not expecting much but then she connects with a sexy beta. And when she meets his Alphas, they set her body on fire. Maybe, she's found her no-strings-attached heat pack. Maybe, she's found something more. I could not connect with the characters in this book, so their story never resonated with me. And there was no love story; there was sex. Grey made it clear from the beginning that he had a true love and it was his beta boy, Rian. He went so far as to reassure Rian “Say the word, I’ll never touch her again. Lucas can put the babies in her. I only need you, beta boy”. So, Madison was there for babies, no emotions needed. Nice. No, thank you. I want the Omega to be the center of their world, not an incubator. Lucas and Rian weren't any better. After her heat, they let her leave. Not one of them made her feel valued. No one gave her a reason to stay or even offered a cuddle. And the sex didn't even come across as mind-blowing. Madison deserved better.
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Reviewed in the United States on March 11, 2025

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