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Description
Mouse Anti-Human CD8α Antibody (S-3972)Product Specification Host Mouse Antigen CD8 Synonyms T cell surface glycoprotein CD8 alpha chain; T lymphocyte differentiation antigen T8 Leu 2; MAL; CD8A Location Secreted, Cell membrane Accession P01732 Clone Number S 3972 Antibody Type Mouse mAb Isotype IgG2a Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4 Stability &
Product Specification
| Host | Mouse |
| Antigen | CD8α |
| Synonyms | T-cell surface glycoprotein CD8 alpha chain; T-lymphocyte differentiation antigen T8/Leu-2; MAL; CD8A |
| Location | Secreted, Cell membrane |
| Accession | P01732 |
| Clone Number | S-3972 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:2000 | Hu |
Background
CD8α is a crucial immune glycoprotein that plays a vital role in the immune response by serving as a co-receptor for the T-cell receptor (TCR) on cytotoxic T cells. It forms either a homodimer (α/α) or a heterodimer with CD8β (α/β) to interact with MHC class I molecules on antigen-presenting cells (APCs), facilitating the recognition of intracellular pathogens such as viruses. CD8α also recruits the LCK kinase, which initiates downstream signaling pathways essential for T-cell activation and proliferation. This molecule is critical for the function of cytotoxic T lymphocytes (CTLs) and is involved in various immune-related diseases, including immunodeficiencies and autoimmune conditions.
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
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4.1 ★★★★★
Based on 1450 reviews
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Product Reviews
★★★★★ 5
Make sure you get this brand. The look alikes are trash!
Very durable and fun! My Pitbull chews on this constantly and loves to have treats or peanut butter, put in the bottom of it as an extra treat. A friend of mine bought a similar looking toy that was destroyed by her pitbull in moments. This one is better quality and has stood the test of this power chewer. The rubber is very thick and he chews it constantly but it stays in tact. It is soft enough to squeak if he gets a hold of it just right, but that’s the rare treat. The size is perfect for my 80 pound boy. I am also able to throw these toys in his pool for him to dive for them. Definitely in great value for the price.
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Reviewed in the United States on March 19, 2026
★★★★★ 4
Indestructible, but maybe too much?
Color: Orange, Size: Medium
Not too enticing for my dog, but, it is definitely indestructible! He chews on it every so often, but less than I had expected. I think the material is so rock hard that it offers little incentive for him to chew on it.
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Reviewed in the United States on May 27, 2026
★★★★★ 5
Best I've Tried
Color: Blue Shark, Size: Medium
With my pitty pup, there's no such thing as an indestructible toy, but this has been the most impressive so far. It's lasted days vs the typical minutes his new toys survive. It has a squeaker, but no fluff, and this has been great. He's been trying to get at if for a long time with no success! He has tore thru the rubber portion, but there's still plenty of play left in this toy. The 3 different textures keep him interested vs the hard material toys he rejects or chews on them too long and I worry about tooth wear. Definitely buying more.
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Reviewed in the United States on June 7, 2026
★★★★★ 5
This has been a challenge for my extreme chewer! The toy is winning
Color: Green
Indestructible? Not for my pitbull. Except on this toy. She has slowly chewed some of the outer portion on the backside, but it still has a lot of gnawing time left. This is her go-to toy now. she carries it nearly everywhere. She loves it. I am amazed at how well it is holding up. Within minutes, hours or a few days, the other "indestructible" toys I've purchased, never survived as described.
This is a heavy toy! Not for the weak! I cannot stress enough the extreme chewer my dog is. Yet, I can see this toy lasting months. It won't be pretty then but it will most likely still be a favorite chew toy. I'm glad I found this and will be buying more.
FYI's... 1) Chewability-5 stars 2) Softness-1 star, it's solid but chewable, 3) Bounce-0 stars, No bounce, it's heavy!, Playability- 5 stars. My dog plays with it, lets it lay with her when resting. Nearly always within her reach. She sleeps with it! That's love.
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Reviewed in the United States on January 2, 2026
★★★★★ 5
My buddy has been chewing on this for an hour!
Color: Green, Color: Green
This dog toy has been a great addition to our dog’s toy collection! My dog can be a pretty aggressive chewer, so I’m always looking for toys that are durable and can actually hold up to daily play. This one has been surprisingly tough and has lasted much longer than many other toys we’ve tried.
The material feels strong and well made, and the design makes it easy for my dog to grip and chew. He loves carrying it around and tossing it during playtime. It’s also great for keeping him busy and helping reduce boredom, especially when he has extra energy to burn.
Another thing I like is the texture of the toy. It seems to help keep my dog engaged, and it’s sturdy enough that I don’t worry about it falling apart right away like some softer toys do. It’s been used for chewing, tugging, and even some fetch around the house, and it’s still holding up really well.
The only small drawback is that I wish it had a squeaker inside. My dog absolutely loves squeaky toys, and I think that would make it even more exciting and keep him interested for longer periods of time.
Overall though, this is a very solid and durable dog toy that’s perfect for dogs that love to chew. If you’re looking for something tough that can help keep your dog entertained and reduce boredom, this is definitely worth try
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Reviewed in the United States on March 12, 2026