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Description
MAP3K1 Recombinant Rabbit mAb (S-3097-61)Product Specification Host Rabbit Antigen MAP3K1 Synonyms Mitogen activated protein kinase kinase kinase 1; MAPK ERK kinase kinase 1 (MEK kinase 1; MEKK 1); MAPKKK1; MEKK; MEKK1 Immunogen Synthetic Peptide Location Cytoplasm Accession Q13233 Clone Number S 3097 61 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt, Mk Positive Sample 293T, SH SY5Y, A431, A549, EL4, NIH 3T3, mouse testis, mouse embryo, rat testis, COS 7
Product Specification
| Host | Rabbit |
| Antigen | MAP3K1 |
| Synonyms | Mitogen-activated protein kinase kinase kinase 1; MAPK/ERK kinase kinase 1 (MEK kinase 1; MEKK 1); MAPKKK1; MEKK; MEKK1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm |
| Accession | Q13233 |
| Clone Number | S-3097-61 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | 293T, SH-SY5Y, A431, A549, EL4, NIH/3T3, mouse testis, mouse embryo, rat testis, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
Background
MAP3K1 (MEKK1) is a 196-kDa serine/threonine kinase that sits at the hub of multiple signaling cascades: it functions as the apical MAP3K in the classical ERK5 and JNK pathways, phosphorylating and activating MKK5 and MKK4/7 respectively, while also cross-talking to the canonical NF-κB axis by catalyzing IKKβ phosphorylation; beyond kinase activity it acts as a ubiquitin E3 ligase that targets downstream adaptors such as TRAF2 and DUSP1 for degradation, thereby fine-tuning stress, cytokine and receptor-tyrosine-kinase responses; gain-of-function missense mutations clustered in its N-terminal PH domain and C-terminal kinase domain are among the most frequent genomic events in estrogen-receptor-positive breast and endometrial cancers, where they enhance transcription of ER-dependent proliferative genes, drive anti-apoptotic signaling and confer resistance to endocrine therapies, making MAP3K1 both a key integrator of cellular stress decisions and an actionable driver of luminal-type women’s cancers.
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