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Description
COL1A1 Recombinant Rabbit mAb (S-2975-9)Product Specification Host Rabbit Antigen COL1A1 Synonyms Collagen alpha 1(I) chain; Alpha 1 type I collagen; Cola1; Col1a1 Immunogen Synthetic Peptide Location Secreted Accession P11087 Clone Number S 2975 9 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, IF Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0.
Product Specification
| Host | Rabbit |
| Antigen | COL1A1 |
| Synonyms | Collagen alpha-1(I) chain; Alpha-1 type I collagen; Cola1; Col1a1 |
| Immunogen | Synthetic Peptide |
| Location | Secreted |
| Accession | P11087 |
| Clone Number | S-2975-9 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, IF |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:5000 | Hu, Ms |
| IHC-P | 1:2000 | Hu, Ms, Rt |
| ICC | 1:500 | Hu |
| IF | 1:100 | Ms, Rt |
Background
COL1A1 (collagen type I alpha 1 chain) is the ~1,464-amino-acid pro-alpha1 strand that, together with two COL1A2 pro-alpha2 strands, assembles the triple-helical type I collagen—the main load-bearing protein of bone, skin, tendon, dentin and most connective tissues; after secretion, its N- and C-propeptides are cleaved by BMP-1/tolloid proteases, allowing the rigid 300-nm collagen fibrils to form and then be mineralized (in bone) or cross-linked (in soft tissues), while intracellularly it requires proline and lysine hydroxylation, endoplasmic-reticulum chaperones and trimer registration to prevent misfolding; mutations cause osteogenesis imperfecta, Ehlers–Danlos syndrome, Caffey disease and fibrosis, and its expression is driven by the Sp1/3, TGF-β/Smad and HIF pathways, is up-regulated in fibrosis and cancer stroma, and serves as a biomarker for tissue repair and invasiveness.
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