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Description
ARIH1 Recombinant Rabbit mAb (S-3166-64)Product Specification Host Rabbit Antigen ARIH1 Synonyms E3 ubiquitin protein ligase ARIH1; H7 AP2; HHARI; Monocyte protein 6 (MOP 6); Protein ariadne 1 homolog (ARI 1); UbcH7 binding protein; ARI; MOP6; UBCH7BP Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q9Y4X5 Clone Number S 3166 64 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu, Ms, Rt, Mk Positive Sample HeLa, A431, MCF7, PC 3, NIH 3T3, C6, COS 7
Product Specification
| Host | Rabbit |
| Antigen | ARIH1 |
| Synonyms | E3 ubiquitin-protein ligase ARIH1; H7-AP2; HHARI; Monocyte protein 6 (MOP-6); Protein ariadne-1 homolog (ARI-1); UbcH7-binding protein; ARI; MOP6; UBCH7BP |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q9Y4X5 |
| Clone Number | S-3166-64 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, ICC |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | HeLa, A431, MCF7, PC-3, NIH/3T3, C6, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| ICC | 1:500 | Hu, Ms |
Background
ARIH1 (Ariadne RBR E3 ubiquitin-protein ligase 1) is a 557-amino-acid RING-between-RING (RBR) E3 ligase that ubiquitinates multiple substrates—most notably DNA-PKcs, whose proteasomal degradation activates the cGAS-STING pathway to enhance anti-tumor immunity, while in colorectal cancer it instead promotes K63-linked ubiquitination of PHB1 to drive mitochondrial respiration and tumor progression—thereby acting as a context-dependent regulator of proliferation, DNA repair, epithelial-mesenchymal transition and immune evasion through its dynamic interactions with E2 enzymes and cullin-RING ligase complexes.
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