SKU: 50353089028

CD30/TNFRSF8 Fc Chimera Protein, Mouse

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Description

CD30/TNFRSF8 Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms CD30; CD30KI 1; CD30L receptor; D1S166EKi 1; TNFRSF8 Accession Q60846 Amino Acid Sequence Phe19 Thr281, with C hIgG Fc Expression System HEK293 Molecular Weight 72 95kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Physical Appearance Lyophilized Powder Storage Buffer PBS, 5% trehalose, PH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid

Product Specification


Species Mouse
Synonyms CD30; CD30KI-1; CD30L receptor; D1S166EKi-1; TNFRSF8
Accession Q60846
Amino Acid Sequence Phe19-Thr281, with C-hIgG Fc
Expression System HEK293
Molecular Weight

72-95kDa (Reducing)
Purity ＞95% by SDS-PAGE
Endotoxin <0.1EU/μg
Physical Appearance Lyophilized Powder
Storage Buffer PBS, 5% trehalose, PH7.4
Reconstitution Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.
Stability & Storage · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.
· 3 months, -20 to -80℃ under sterile conditions after reconstitution.
· 1 week, 2 to 8℃ under sterile conditions after reconstitution.
· Please avoid repeated freeze-thaw cycles.
Reference

1. Oflzoglu E. et al. (2009) Adv. Exp. Med. Biol. 647:174
2. Kennedy, M.K. et al. (2006) Immunology 118:143.
3.Tarkowski, M. (2003) Curr. Opin. Hematol. 10:267.

Background

CD30, also known as Ki-1 antigen and TNFRSF8, is a 120 kDa type I transmembrane glycoprotein belonging to the TNF receptor superfamily. Mature mouse CD30 consists of a 264 amino acid (aa) extracellular domain (ECD) with three cysteine-rich repeats, a 27 aa transmembrane segment, and a 190 aa cytoplasmic domain. In contrast, human CD30 includes an additional 90 aa in the ECD and contains six cysteine-rich repeats. CD30 is normally expressed on antigen-stimulated Th cells and B cells. However, it is upregulated in Hodgkin’s disease (on Reed-Sternberg cells), other lymphomas, chronic inflammation, and autoimmunity. CD30 binds to CD30 Ligand/TNFSF8 which is expressed on activated Th cells, monocytes, granulocytes and medullary thymic epithelial cells. In B cells, CD30 ligation promotes cellular proliferation and antibody production in addition to the expression of CXCR4, CCL3,and CCL5. An 85 ‑ 90 kDa soluble form of CD30 is shed from the cell surface by TACE-mediated cleavage. Soluble CD30 retains the ability to bind CD30 Ligand and functions as an inhibitor of normal CD30 signaling.

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SKU: 50353089028

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4.2 ★★★★★
Based on 394 reviews
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Product Reviews
J
Verified Purchase
Jeffrey T. Munson
Boise, US
★★★★★ 5
The Island Of Death
Format: Hardcover
On August 7th, 1942, American Marines stormed ashore on Guadalcanal. What lay before them was a six-month odyssey of fighting against the best of what the Japanese had to offer. In this fine book, author Joseph Wheelan describes the battle that turned the tide in the Pacific War. The Japanese had started construction of an airfield on Guadalcanal. If completed, Japanese aircraft would be able to harass American convoys and threaten Australia. The Americans seized the airfield and eventually, planes from the Cactus Air Force began attacking the Japanese. Throughout the book, the reader learns about all phases of the Guadalcanal campaign, including the battles of Alligator Creek and Bloody Ridge. On the sea, the Americans and Japanese slugged it out at Savo Island, as well as the great naval battles of November, 1942. Names such as Chesty Puller, John Baslone, "Archie" Vandegrift, Joe Foss, and "Bull" Halsey became household names in the United States. Each side lost many men, ships, and planes, but the tenacity and, finally, the industrial might and the ability to rapidly replace losses, led the Americans to victory. Never again would the Japanese regain the offensive in the Pacific War. "Midnight in the Pacific" is a very good book, and the author has done a good job of describing all of the main points of the battle. Each chapter is broken down into a single month's worth of action, and the narrative is well-written. Highly recommended.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 25, 2017
L
Verified Purchase
Laurence J. Rusiecki
Dallas, US
★★★★★ 4
Good Narrative History
Format: Hardcover
The account of the Guadalcanal campaign was well-written. It has several good maps but it falls short with the two carrier battles associated with the action. There should have detailed maps for the Battle of the Eastern Solomons and the Battle of the Santa Cruz Islands. Aside from this shortcoming, the book provides an excellent, readable history of a crucial confrontation between the US and Japan.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 7, 2019
D
Verified Purchase
Donald J. Hanson
Pawtucket, US
★★★★★ 5
A Very Thorough Accounting of One of the Most Savage Battles of World War 2
Format: Kindle
My father served in the United States Marine Corps during World War 2 and fought in the first offensive battle by the US during the war, the battle for the island of Guadalcanal. He was seriously wounded there and evacuated back to the states where he spent a year in a naval hospital. As a result, I have read many of the books about this battle. This book was particularly interesting because the author described the battle from the perspective of both the allied forces and the Japanese, drawing from historical records and other books. It was a very thorough accounting and demonstrated what a monstrous battle this was. I only wish my father were still alive so that I could have discussed it with him. His experience at Guadalcanal was not something he would often talk about, but considering savagery of what he saw and endured, I understand. If you are interested in Guadalcanal, I recommend this book.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on October 21, 2017
Q
Verified Purchase
qtjudyg
Port Orchard, US
★★★★★ 5
Excellent book on the Campaign!
Format: Hardcover
I highly recommend this book! I have read many books on the Guadalcanal Campaign and I rate this one at the top. It has just the right blend of stragity and personal accounts to keep the story interesting. It is actually a real page-turner, which is rare for a non-fiction work. Wheelan writes in a style that reminds me of the books I read in my teens by Cornelius Ryan and John Toland, which captured my interest in WWII and history. The book jumps right into the invasion, no multiple chapters concerning the planning and build up, but this info is covered later. All phases of this campaign are covered; ground, air and sea. The maps are okay. There are never enough. The author skims over much of the U. S. Army battles after the Marines are relieved, but that seems to be a trend in all of the books on Guadalcanal that I have read. Overall, this is an excellent book for those who want to learn about the campaign and those who need a re-fresher after reading Starvation Island and Guadalcanal by Frank in years past.
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Reviewed in the United States on October 1, 2017
D
Verified Purchase
Douglas B. Schonour
Louisville, US
★★★★★ 5
Most complete coverage of Guadalcanal I have read.
Format: Kindle
I have read dozens of WWII books and many touched on the Guadalcanal Battle. I thoroughly enjoyed The Big E and its involvement in the battle. Thas book covered the entire conflict from start to finish. Frankly, I hated to see the book end. The courage and tenacity of all those involved was amazing. To understand the miserable conditions in the area where these men fought was inspiring. To see this battle through the eyes of the American forces and Japanese forces was an added bonus. Thank you for a great read!!!
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Reviewed in the United States on February 1, 2024

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