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Description
Synaptopodin Recombinant Rabbit mAb (SDT-3331-4)Product Specification Host Rabbit Antigen Synaptopodin Synonyms KIAA1029; SYNPO Immunogen Synthetic Peptide Location Cytoplasm, Cytoskeleton, Synapse Accession Q8N3V7 Clone Number SDT 3331 4 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Hu, Ms, Rt Positive Sample mouse brain, rat brain Purification Protein A Concentration 0. 25 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol,
Product Specification
| Host | Rabbit |
| Antigen | Synaptopodin |
| Synonyms | KIAA1029; SYNPO |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cytoskeleton, Synapse |
| Accession | Q8N3V7 |
| Clone Number | SDT-3331-4 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | mouse brain, rat brain |
| Purification | Protein A |
| Concentration | 0.25 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000-1:5000 | Ms, Rt |
| IHC-P | 1:2000 | Hu, Ms, Rt |
| IF | 1:2000 | Hu |
Background
Synaptopodin is an actin-associated protein concentrated in ~30 % of large dendritic spines of telencephalic neurons where it nucleates the spine apparatus—stacks of smooth endoplasmic reticulum that function as local calcium stores and sites of protein synthesis—thereby enabling PKA- and activity-dependent enlargement of spine heads, trafficking of GluA1-containing AMPA receptors, and the expression of long-term potentiation and memory formation, so that synaptopodin-deficient mice lack spine apparatuses, show blunted LTP, and exhibit impaired spatial learning.
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