SKU: 47322875315

Carbonic Anhydrase IX/CA9 His Tag Protein, Cynomolgus

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Description

Carbonic Anhydrase IX/CA9 His Tag Protein, CynomolgusProduct Specification Species Cynomolgus Synonyms Carbonate dehydratase IX, Carbonic anhydrase IX (CA IX; CAIX), Membrane antigen MN, P54 58N Accession A0A2K5VQG9 Amino Acid Sequence Gln38 Leu398, with C terminal His Expression System HEK293 Molecular Weight 40 50 kDa (Reducing) Purity 95% by SDS PAGE &95% by SEC HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, 5% trehalose, pH7.

Product Specification


Species Cynomolgus
Synonyms Carbonate dehydratase IX, Carbonic anhydrase IX (CA-IX; CAIX), Membrane antigen MN, P54/58N
Accession A0A2K5VQG9
Amino Acid Sequence Gln38-Leu398, with C-terminal His
Expression System HEK293
Molecular Weight

40-50 kDa (Reducing)

Purity >95% by SDS-PAGE &>95% by SEC-HPLC
Endotoxin <0.1EU/μg
Conjugation Unconjugated
Tag His Tag
Physical Appearance Lyophilized Powder
Storage Buffer PBS, 5% trehalose, pH7.4,
Reconstitution

Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation.

Stability & Storage

· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃.

· 3 months, -20 to -80℃ under sterile conditions after reconstitution.

· 1 week, 2 to 8℃ under sterile conditions after reconstitution.

· Please avoid repeated freeze-thaw cycles.

Reference

Supuran CT. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat Rev Drug Discov 2008; 7:168-81.
McDonald PC, Swayampakula M, Dedhar S. Coordinated regulation of metabolic transporters and migration/invasion by carbonic anhydrase IX. Metabolites 2018;8: E20.

Background

The CAIX works as a dimeric molecule composed of two monomeric proteins liked with a disulfide bond between cysteine residues of the two CAIX monomers, while the structure of CAXII is stabilized by 19 hydrogen-bonded interactions in the dimer interface. Carbonic anhydrases IX and CAXII (CAIX/CAXII) are transmembrane zinc metalloproteins that catalyze a very basic but crucial physiological reaction: the conversion of carbon dioxide into bicarbonate with a release of the proton. CAIX functions with bicarbonate transporters (including electroneutral bicarbonate transporter NBCn1 (SLC4A7)) to bring in HCO3- produced in a CAIX-mediated hydration reaction of CO2, and amino acid transporters (including the large neutral amino acid transporter 1 (LAT1) and CD98 heavy chain (CD98hc)) to transport in essential amino acids and glutamine (via interaction with glutamine transporter SLC1A5 and sodium-coupled neutral amino acid transporter 2 (SNAT2) facilitating the uptake of amino acid by SLC1A5), which cancer cells employ as an alternative metabolic energy source and biosynthetic precursor. CAIX also creates unique interactions with collagen- and laminin-binding integrins at the leading edge of migrating cells.

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SKU: 47322875315

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Well this product works. At first I thought maybe the Caribbean sun wasn’t as bad as people said since I was in the sun for 4 days wearing this sunscreen and hardly had tan lines, then I tested my theory for 1 day with another brand and got a sunburn. I took star off (would really only do a half if it allowed) for when you go in the water or if you sweat there is a bit of white residue that it leaves. But for sun purposes, if you want protection, I highly recommend.
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Size: 6.7 Fl Oz (Pack of 1), Size: 6.7 Fl Oz (Pack of 1)
Neutrogena Beach Defense SPF 50 is an absolute game-changer when it comes to sun protection. Whether you're relaxing at the beach, swimming, or enjoying an outdoor adventure, this sunscreen provides broad-spectrum protection that effectively shields the skin from harmful UVA and UVB rays. One of its standout features is its lightweight texture, it glides effortlessly onto the skin without feeling greasy or heavy. Unlike some sunscreens that leave a sticky residue, Beach Defense absorbs quickly and smoothly, making it ideal for both face and body application. Another major plus? Water resistance! This formula stays put, even after swimming or sweating, ensuring continuous protection throughout the day. And despite its strong defense against the sun, it feels refreshing and comfortable on the skin, making reapplication a breeze. I used it during a vacation in the Dominican Republic, and me and my family enjoyed it. My 5 years old girl has been protected from the sun all the time. If you're looking for reliable, effective, and easy-to-use sun protection, this sunscreen is an excellent choice. Highly recommended! ☀️👌
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Great sunscreen product.
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This sunscreen works great. It’s light and doesn’t feel greasy on your skin. I use it all the time.
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