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Description
Human LCK, His tagProduct Specification Species Human Accession P06239 Amino Acid Sequence Protein sequence(P06239, Asn64 Thr226, with C 10*His) NLVIALHSYEPSHDGDLGFEKGEQLRILEQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRKDAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFPGLHELVRHYTNASDGLCTRLSRPCQTGGGGSHHHHHHHHHH Expression System HEK293 Molecular Weight Theoretical: 20. 1kDa Actual: 24 30kDa Purity >90% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated
Product Specification
| Species | Human |
| Accession | P06239 |
| Amino Acid Sequence | Protein sequence(P06239, Asn64-Thr226, with C-10*His) |
| Expression System | HEK293 |
| Molecular Weight | Theoretical: 20.1kDa Actual: 24-30kDa |
| Purity | >90% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | Lyophilized from a 0.2 μm filtered solution of 0.2M PBS, pH7.4. |
| Reconstitution | Reconstitute no more than 1 mg/mL according to the size in deionized water after rapid centrifugation. |
| Stability & Storage |
|
Background
Lymphocyte-specific protein tyrosine kinase (LCK) is a member of the Src family of protein tyrosine kinases (PTKs). It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. LCK has emerged as one of the key molecules regulating T-cell functions. Studies using LCK knock-out mice or LCK-deficient T-cell lines have shown that LCK regulates the initiation of TCR signaling, T-cell development, and T-cell homeostasis. Because of the crucial role of LCK in T-cell responses, strategies have been employed to redirect LCK activity to improve the efficacy of chimeric antigen receptors (CARs) and to potentiate T-cell responses in cancer immunotherapy. In addition to the well-studied role of LCK in T cells, evidence has been accumulated suggesting that LCK is also expressed in the brain and in tumor cells, where it actively takes part in signaling processes regulating cellular functions like proliferation, survival and memory. Therefore, LCK has emerged as a novel druggable target molecule for the treatment of cancer and neuronal diseases.
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4.6 ★★★★★
Based on 306 reviews
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Product Reviews
★★★★★ 5
great guide to hiking (or biking) the Camino de Santiago trails
Format: Hardcover
Spain is one of my favorite European destinations, and while I have not done the Camino de Santiago yet, it is an area that is definitely on my radar for an upcoming trip. This book focuses on the trails and the regions they pass through, and gives quite a bit of detail and background to successfully plan a trip there.
Now, I am not religious, and I am purely interested in the historical and cultural aspects of the region, not looking to have a spiritual experience. Fortunately the book is written in such a way that it is respectful to those who *are* looking for the latter, but it doesn't focus on it as much as I feared that it might. So it'll be useful to me in planning my travels.
The one issue that I have about this book, which I *almost* took a star off of my rating for, is that the book is a little *too* sturdy. My big complaint with the regular DK travel guides in recent years is that they've gone to cheaper paper, cheaper covers, and cheaper binding than they used to use, to the point that they feel almost fragile to me. This book, ironically made as a guide for hiking and biking trips, has the opposite problem... It's hardcover, and it's kind of bulky. I mean, that's great, normally I'd be in favor of that... But if I'm going to be hiking for days or weeks (some of the trails in this book take over three weeks to complete according to the book), the last thing I'm going to want to do is carry this thing around. It's a little baffling that they'd choose this of all books to make hardcover.
Honestly, though, I am probably not hiking (at least not for a multi-week trail... maybe for a few days in there, for the rest I'll take a train or rent a car), which is why I decided not to remove a star. But if you will be hiking, it may be something you'll want to consider.
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Reviewed in the United States on November 9, 2025
★★★★★ 5
Very beautiful book
Format: Hardcover
It’s not only a tour guide but rather a detail record of the Camino de Santiago history book and the pictures inside this book look so beautiful you may only find in specialized photo albums.
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Reviewed in the United States on January 14, 2026
★★★★★ 5
Wonderful resource
Format: Hardcover
This spectacular pilgrim guide title Walking the Camino de Santiago, is an excellent production that provides helpful guidance on anything a pilgrim would need to know prior to making this well-known pilgrimage via some not-so-well-known routes and tips. This book stands out in excellence with its simplicity and yet thoroughness in providing chapters on the possible eight pilgrimage routes with history on each one. It provides tips and practical information on things to check out as part of the geographical and cultural landmarks, food, accommodations, etc. The illustrations and photographs in this book make it a stunning work of art and resource.
Anyone considering doing this pilgrimage/ retreat would benefit from this book. If nothing else, this book can be gifted to someone considering doing the Camino, and it would make an excellent coffee table conversation starter.
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Reviewed in the United States on December 27, 2025
★★★★★ 3
Small hardcover: get the Kindle version instead
Format: Hardcover
This is a small format hardcover with 6.5 x 8.5 inch pages. As an armchair traveler I was hoping for more illustrations and I also found the small print, generally small photos and illustrations and the small captions on the illustrations quite frustrating. I would actually recommend the Kindle version instead since it is less expensive and allows you to better expand the illustrations to get a much better view. There’s a good description of eight of the more popular Caminos including the best known “French Way” which stretches almost 500 miles from the French border area to Santiago de Compostole in Western Spain. Learning about the history of the pilgrimage routes which stretches back more than 1000 years was interesting and the maps provide a good general sense of the different routes. The day by day accounts tend to be a bit boring without larger illustrations. This is a decent introduction for someone like me who only thought there was a single Camino de Santiago. Still I wish I had the Kindle version instead of the print version in this case.
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Reviewed in the United States on March 6, 2026
★★★★★ 4
Great Book for Choosing a Camino de Santiago Route with Distinctive Descriptions and Photos
Format: Hardcover
This DK travel guide is a little unusual in that it does not primarily focus on the things to see, places to eat, and places to stay, although brief suggestions are included. Instead, the book describes eight main routes of the Camino de Santiago in 2-to-3-day sections, plus some alternate routes and extensions, touching on the scenery and the history of the walk. Suggested cafes and albergues (pilgrim hostels) are relegated to small paragraphs that resemble captions. Arguably there are days when there won’t be much to see or do, just long meditative walks between farm fields or vinyards; also, the rigors of the walk may leave pilgrims too tired to explore much. As the guide says, “you’re not a vacationer, you’re a pilgrim.”
Of course, there are helpful tips included, particularly in the back of the book where culture, etiquette, transportation, and training are discussed, but also some trail-specific advice throughout. For example, some routes like the Portuguese route allow for returning to the same hotel for several nights by utilizing trains to access different sections of the route. The distinctiveness of the various routes makes this a helpful book if you’re intrigued but not sure which of the routes would be right for you. You'll be left with a little more work to do to find contact information and seasonal operating hours for the listed places.
The layout of the book features lots of pictures, as might be expected for a DK travel book, but the pages are not glossy and there are none of the cutaways and drawings which make DK books so recognizable. The book feels more like an engaging textbook than a typical travel guide. It seems to be an intentional decision not to carry paragraphs across pages, which gives the reader the opportunity to look at the pictures and captions before continuing. There are some artistic details like wavy-line swooshes that overlay the photos and unfortunately often make them look as though something is wrong with the print, but otherwise, the writing, design, and layout make the information very accessible.
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Reviewed in the United States on February 17, 2026
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