AIE carboxyl-modified fluorescent nanoparticles in NIR-I

AIE carboxyl-modified fluorescent nanoparticles in NIR-IProduct Name AIE carboxyl modified fluorescent nanoparticles in NIR I Product Overview AIE molecules usually do not fluoresce or fluoresce weakly in solution, but emit strong fluorescence in the aggregated state. By encapsulating AIE molecules in polystyrene microspheres or polymers, their fluorescence efficiency can be increased and the effect of the external environment on the AIE molecules can be reduced. This restricts the movement of the AIE

Product Name

AIE carboxyl-modified fluorescent nanoparticles in NIR-I

Product Overview

AIE molecules usually do not fluoresce or fluoresce weakly in solution, but emit strong fluorescence in the aggregated state. By encapsulating AIE molecules in polystyrene microspheres or polymers, their fluorescence efficiency can be increased and the effect of the external environment on the AIE molecules can be reduced. This restricts the movement of the AIE molecules and reduces the non-radiative leaps, thus increasing the fluorescence intensity. The encapsulation of microspheres can protect AIE molecules from external factors and improve their stability. At the same time, various functional groups can be introduced on the surface of the wrapped material, such as carboxyl groups for coupling antibodies.

Technical Parameter 

Appearance：Malachite blue dispersion

Diameter:5-120 nm

Concentration:mg/mL

Solvent：Water

Absorption peak：~633nm

Fluorescence peak：~785nm

Modified group:-COOH

Product Features

1. Strong fluorescence emission: it can show strong fluorescence in the aggregated state, which overcomes the problem of fluorescence burst when traditional fluorescent materials are aggregated. 

2. Good light stability: It is not easy to photobleach, and can maintain stable fluorescence performance under prolonged illumination, which is suitable for long-term monitoring and imaging. 

3. Low background interference: in the organism, due to its unique luminescence mechanism, it can effectively reduce the background fluorescence interference of the biological tissues themselves and improve the clarity and accuracy of imaging. 

4. Easy functional modification: various functional groups can be introduced through chemical modification to achieve specific functions such as target recognition and drug loading to meet different biomedical applications. 

5. Good biocompatibility: After appropriate surface modification, it can reduce the biotoxicity and improve the safety and applicability in the organism.

Application Fields

1. Bio-imaging: AIE materials can be used for cell imaging, tissue imaging and in vivo imaging. For example, AIE nanoparticles can specifically target cancer cells or organelles for early diagnosis of tumours and treatment monitoring. 

2. Biological detection: AIE materials can be used as fluorescent probes for the detection of biological molecules, such as proteins, nucleic acids and pathogens. Through specific binding with target molecules, the fluorescence signal of AIE materials will change, thus achieving the detection and quantitative analysis of target molecules. 

3. Drug delivery: AIE materials can be used to construct drug delivery systems to achieve targeted delivery and controlled release of drugs. For example, AIE nanoparticles can be loaded with drug molecules, and through surface modification to achieve targeted recognition and internalisation of tumour cells, improving the therapeutic effect of drugs. 

4. Photodynamic therapy: AIE materials can generate reactive oxygen species, such as monoclinic oxygen, under light to kill cancer cells or pathogens, and AIE materials can be used as photosensitizers for photodynamic therapy to achieve non-invasive treatment of tumours. 

5. Gene therapy: AIE materials can be used for gene delivery and gene expression regulation. For example, AIE nanoparticles can be loaded with gene molecules, and through surface modification to achieve targeted recognition and internalisation of cells, improving the efficiency of gene therapy.

Related Information

Storage: sealed, preserved at 4-8¡ãC/span>

Period of validity: 6 months

Please e-mail for the detailed characterization data.

E-mail:[email protected]